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Safety,Applicability and Efficacy Test of Cosmetics in China


1. Chemical tests:

l          Heavy metals: lead, arsenic, mercury, cadmium, chromium, zirconium, neodymium, beryllium, antimony, thallium, strontium, selenium and so on.

l          Components for hair: mercaptoacetic acid, selenium disulfide.

l          Preservatives: Nipagin esters, phenoxy ethanol, benzyl alcohol, salicylic acid, sorbic acid, formaldehyde, acetic acid dehydrogenation, dichlorobenzyl methanol, boric acid, benzoic acid, benzoyl peroxide, etc.

l          Sex hormones: estradiol, estriol, diethylstilbestrol, testosterone, methyl testosterone, progesterone.

l          Sun-screening agent: phenyl benzimidazole sulfonic acid, benzophenone-4 and benzophenone -5, p-aminobenzoic acid, diphenyl ketone -3, p-methoxy cinnamic acid isoamyl ester, 4-ethylbezilidene camphor, PABA ethylhexyl ester, Butyl methoxydibenzoylmethane, Octocrylene, methoxy-cinnamic acid ethylhexyl ester, salicylic acid ethylhexyl ester, homosalate, ethylhexyl triazone, methylenebis-Benzotriazole -4-methyl-phenol), bisethylhexyl phenol methoxyphenyl triazone.

l          Hair dying agent: p-phenylene diamine, hydroquinone, m-amino-phenol, o--phenylenediamine, p-aminophenol, toluene 2,5 - diamine, resorcinol, p-methylaminophenol.

l          |á-hydroxy acids: tartaric acid, glycolic acid, malic acid, lactic acid, citric acid.

l          Antibiotics: dihydrate oxytetracycline, tetracycline hydrochloride, chlortetracycline hydrochloride, chloramphenicol and metronidazole.

l          Vitamins: vitamin D2, vitamin D3, vitamin E and acetates


2. Microbial Test

l          Total bacteria count,

l          fecal coliform,

l          Staphylococcus aureus,

l          Pseudomonas aeruginosa,

l          Shigella,

l          Pseudomonas aeruginosa,

l          Mold and yeast.

3. Animal Test (in accordance with Hygienic Standard for Cosmetics):

l          Acute oral toxicity test

l          Acute percutaneous toxicity test

l          Acute and repeated skin irritation / corrosion test

l          Acute eye irritation / corrosion test

l          Skin hypersensitivity / allergy test

l          Skin phototoxicity test

l          Sub-chronic percutaneous toxicity test


4. Animal substitution test (In accordance with OECD, the industry standards of EU and inspection and quarantine):

l          3T3 neutral red absorption phototoxicity test

l          Acute keratinocyte toxicity test

l          Acute 3T3 cell toxicity test

l          Hen's egg test-chorioallantoic membrane test for eye irritation / corrosion test

l          Stem cell test for embryo and developmental toxicity


5. Applicability and Efficacy Tests

l          Human skin patch test (deodorant category / sunscreen category / spot-dispelling category)

l          Cosmetics SPF determination (human test)

l          Cosmetics SPA determination (human test)

l          Waterproof property test of sunscreen cosmetics (human test)

l          Efficacy evaluation on moisturizing cosmetics

l          Efficacy evaluation on anti-fat cosmetics

l          Efficacy evaluation on anti-wrinkle cosmetics

l          Efficacy evaluation on whitening cosmetics






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